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Metformin significantly increased the risk of DPN in patients with vitamin B12 deficiency, whereas metformin treatment in preexisting DPN patients did not increase but rather reduced the risk of vitamin B12 deficiency (173)

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Effects of insulin deficiency or excess on hepatic gluconeogenesis flux during glycogenolytic inhibition in the conscious dog

It also induces immunogenic cell death (ICD) in colon cancer (CT26) and melanoma (B16-F10) cells by elevating the protein expression of CRT, HSP70, and HMGB1, which are important in anti-tumor responses [895]

The compound is expensive to synthesize due to its length and D-amino acid composition