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and Lindner et al

[64] ADP-ribosylation involves either the addition of a single ADP-ribose moiety, in mono-ADP-ribosylation , or the transferral of ADP-ribose to proteins in long branched chains, which is called poly(ADP-ribosyl)ation

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Its safety profile is excellent, with no known serious side effects, and it has even shown potential in DNA repair and tumor suppression through beneficial epigenetic modulation
