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received funding from the Biostime Institute for Nutrition & Care - BINC Foundation, which also contributed to the research directly, and Food for Health Ireland through the EI Technology Centre award (TC20180025)

Once accepted, the following treatment plan is initiated: Cell Therapy Dosing and Delivery: Adjunctive Regenerative Therapies: Supportive Interventions: The average duration of treatment stay is 10 to 14 days, including daily monitoring, lab analysis, and personalized care adjustments

IR/IGF1R DKO brown preadipocytes were obtained as previously described (15, 40)

And we confirmed the study is reported under ARRIVE guidelines

We would like to thank Marianne Seierstad Andresen and Marie- Christine Mowinckel for their assistance with the TaqMan, western blot and multiplex ELISA