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Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma

Average fluorescence values across all pixels within the circle were measured

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The treatment attenuated VPA-induced behavioral abnormalities in both Y-maze and social play tests, while also restoring prefrontal SOD and GSH-Px activity and normalizing VPA-related changes in neuronal number and soma size (Margedari et al., 2024)
