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By week 36, this weight loss effect was even more pronounced, increasing from 9.4% to 14.7%, while the placebo group saw a reduction of only 2.3%

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The 2026 Evidence for Kisspeptin in PMOS A landmark 2024 pre-clinical study published in Human Reproduction found that targeted inhibition of ARC kisspeptin-expressing neurons in a mouse model of PMOS lowered LH pulse frequency and restored normal androgen concentrations