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This goes beyond diet and physical activity, which are important

Apart from the beneficial effects and detrimental side effects of melanin production, melanocytes can also protect against microbial infections by acting as antigen-presenting cells producing cytokines, phagocytosing microorganisms, and degrading both phagocytosed bacteria and bacteria in the microenvironment by means of melanosomal lysosomal enzymes [4, 6, 7]

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When the new impost law (which was, in fact, a continuation of former similar acts) and the proposed Stamp Act reached America, discontent was every where visible