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Oxidized fat was shown to upregulate PPAR and OCNT2 and lead to reduced rate of weight gain compared to controls, indicating an impairment of the feed conversion ratio [112]

People with impaired FMO3 activity either due to genetic variants known to cause trimethylaminuria or due to liver disease have reduced ability to clear TMA

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[DOI] [PubMed] [Google Scholar] 57.Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis
