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In addition to hereditary hemoglobinopathies, aberrant Gardos channel activity has been associated with storage lesions, wherein increased intracellular Ca 2+ concentrations progressively activate the channel, leading to cellular shrinkage and diminished deformability under extended refrigeration (11, 36)

In both pathways, iron overload led to an overall reduction in the expression levels (cardiac muscle contraction pathway Figure 7A and citrate cycle Figure 7B)

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Dietary L-carnitine improves glycogen and protein accumulation in Nile tilapia via increasing lipid-sourced energy supply: an isotope-based metabolic tracking