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This metabolic stress activates autophagy through AMPK-dependent signaling, thereby exerting anticancer effects (105)

The heart was then cut down, frozen for 2 h, and cut into eight slices using a scalpel blade and stained in a Na 2 HPO 4 /NaH 2 PO 4 solution (2:1 ratio of 0.1 M stock solutions until pH 7.4) with 10 mg/mL 2,3,5-triphenyltetrazolium chloride (TTC) (Sigma-Aldrich) to identify the area at risk (AAR) and infarcted area (IA, white in appearance), respectively

The percent change from baseline at 3-min post-exercise BL level was as follows: LCR (-17.2%) and PLA (-1.46%)

doi: 10.3390/jcm13195794 123 BannoYNomuraMHaraRAsamiMTanakaKMukaiYet al

This paper presents the first-in-human study of an AAV replacement therapy for infants with SMA-I