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For instance, even efficient tools such as AlphaFold are able to predict protein folding but still fail in RNA structure prediction, because the molecular constraints followed by RNA molecules are not fully known yet [166]

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Ethics statement All animal experiments were conducted in accordance with protocols approved by the Institutional Animal Care and Use Committee at Ningbo University Health Science Center (AEWC-NBU-2023-186) and Zhejiang Chinese Medicine University Laboratory Animal Research Center (Ethics number:16372)

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