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Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension

3 Cardiovascular disease and gut microbiota 3.1 Overview of CVD Nowadays, CVD has emerged as the leading cause of morbidity and mortality worldwide

In addition, reduced serum testosterone levels in men with DM are an independent factor of endothelial dysfunction, contributing to vascular disease and ED [78], and evidence also showed a decrease in circulating EPC correlates with penile endothelial dysfunction and testosterone levels in DM-associated ED [79]

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