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Mobilization of copper (II) from plasma components and mechanisms of hepatic copper transport

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Compared with the control samples, colitis specimens exhibit significantly higher malondialdehyde (MDA) (58) and iron (particularly, ferrous iron) levels (63), and increased cellular iron levels during ferroptosis induce transcriptional upregulation of ferritin (34), which may contribute to the exacerbation of colitis

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T2D is, however, a multifactorial disease with alterations in lipid and protein metabolism as well as complex interactions between organs, tissues, cell types, and subcellular compartments/organelles