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The truth is simple but often misunderstood: facial fat is usually a reflection of overall body composition, hydration status, and metabolic health not something that can be targeted directly

Goldfischer S, Schiller B, Wolinsky H

doi: 10.1016/j.jep.2005.06.016

For example, gallic acid was found at significant concentrations in the rat brain [72], although the SWISS ADME model predicts that it should not be able to cross the hematoencephalic barrier by passive diffusion

754 Ultimately, the malleability of the human gut microbiome presents exciting opportunities for the development of personalized microbiome-based therapeutics for neurodegenerative diseases