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Protein covalent modification by AGEs results in functional impairment and formation of toxic protein inclusions associated with various NGDs It has been understood that post-translational modification of proteins brings about alteration in the native state structural integrity leading to at least 2 consequences (Figure 1)

Clinical investigations assessing renal biomarkers indicate either neutral or marginally advantageous effects stemming from vitamin D-exercise interventions

21,39 Importantly, the size of a plaque and its obstruction of a vessel opening are unrelated to its stability

it is found in all living creatures

Additionally, measuring real-time redox changes poses a significant challenge for future studies, as ROS and antioxidants operate on very short timescales and in localized cellular compartments, requiring highly specialized techniques for accurate assessment