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Uncertainties and Inconsistencies There are a few uncertainties for consideration: The increase in reactive oxygen species could be the molecular initiating event - while this is true and an increase is ROS is a major contributor and key event to this AOP, proceeding is the event of oxidation of glutathione

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Targeting and therapeutic peptide-based strategies for polycystic kidney disease

Knockdown of Chac2 (Sh-Chac2) via lentiviral transduction significantly reduced its expression at both the mRNA and protein levels, as confirmed by RT-qPCR and Western blot (Fig