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Synthetic peptides, designed as precise agonists, antagonists, or modulators of key receptors like the GLP-1R, MC4R, and GHSR, serve as indispensable tools for this research

doi: 10.3389/fnut.2021.652767 73 Azarcoya-BarreraJLewisEDFieldCJGorukSMakarowskiAPouliotYet al

Together with other mediators, PDGF in turn promotes the metabolic effects of TGF up-regulation, activity of myofibroblasts, and recruitment of fibrotic cells, enhancing the ECM deposition and fibrotic plaque formation (Lucattelli et al., 2008)

Proc Math Phys Eng Sci 467(2132):23102329

Various preclinical models have been created that are showing the impact of metabolism on brain function and in particular the role that impaired metabolism plays in the neurodegeneration processes