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The GSH cycle and biological functions The synthesis of reduced GSH (-L-glutamyl-cysteinyl-glycine) occurs in the cell cytoplasm and involves two ATP-dependent enzymatic steps (Figure 5)

and in differentiating PD from atypical 21 and vascular parkinsonism 25 , with machine-learning-based approaches potentially able to distinguish these at the individual level 26

[DOI] [PubMed] [Google Scholar] 12.Allen RG, Tresini M

Pubmed Abstract Google Scholar View reference in article 2

While this mechanism prevents premature cell death, it simultaneously promotes the accumulation of damaged and dysfunctional cells, which disrupt tissue homeostasis and contribute to the progression of age-related diseases
