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This pathological ROS overproduction is a common final pathway in various forms of acquired hearing loss, including noise-induced and drug-induced (cisplatin) hearing impairment, and current evidence from human studies supporting antioxidant-based interventions remains insufficient (Teraoka et al., 2024)

Role of hypothyroidism and associated pathways in pregnancy and infertility: Clinical insights

3.2.2.4 Nitric oxide (NO) NO, which is mainly produced by different isoforms of nitric oxide synthase (NOS) with arginine as a substrate, is closely associated with vascular endothelial cells and nerve cells, and can cause muscle diastole by increasing cGMP and decreasing Ca 2+ concentrations in smooth muscles through a series of processes

This means focusing on a nutrient-rich diet, incorporating regular exercise (especially strength training to build lean muscle), and prioritizing quality sleep

doi: 10.1038/ncpneuro0421