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It works by stimulating the pancreas to produce insulin in response to food, slowing digestion to promote satiety, suppressing appetite signals, and stimulating the growth of pancreatic beta cells that regulate blood sugar

If these natural mechanisms are disrupted, radicals accumulate in excess and contribute to the development of many diseases

To validate NNMT as an anti-obesity drug target, we investigated the permeability, selectivity, mechanistic, and physiological properties of a series of small molecule NNMT inhibitors

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