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It achieves this by controlling the expression of pluripotency genes through the regulation of GSH homeostasis and the suppression of the mesoderm-inducing protein Brachyury ( The significance of CHAC2-NRF2 signaling pathway extends beyond development

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It participates in amino acid transport through the plasma membrane, scavenges hydroxyl radical and singlet oxygen directly, detoxifying hydrogen peroxide and lipid peroxides by the catalytic action of GPX

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Importantly, the lack of T2 B cells indicated that Gclc is needed in the transition to MZB or their precursors

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