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Interestingly, M1/M2 high tumors were not associated with favorable survival outcome in TCGA and were not predictive marker of response to NAC

Addinsall AB, Cacciani N, Akkad H, et al

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The Influence of the Gut Microbiome on the Neuronal Excitability of AH Neurons In addition to being regulated by enteroendocrine peptides and 5-HT, immune/inflammatory mechanisms, and neurotransmitters, the excitability of AH neurons can also be influenced by the gut microbiome and microbial mediators (FIGURE 5)