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Some dermatologists think that it may be due to a genetic predisposition

While a major concern about the use of immunotherapy in PD treatment is whether antibodies will have significant brain penetration to achieve sufficient target engagement, these engineered fragments might circumvent that issue, as they have higher brain penetrance and faster clearance

doi: 10.1016/j.jnutbio.2005.05.004 157

Sleep: a novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer's disease

If the distribution of confounding factors differs in the two arms, explicative regression analysis will be performed in which the dependent variable will be the normalisation of the serum vitamin B12 concentration, and the independent variable will be the treatment group