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Elevated NAD+ levels activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate numerous metabolic processes including fat oxidation, glucose metabolism, mitochondrial biogenesis, and cellular stress responses

Conflicts of interest Dominique Debray is an adviser for Orphalan

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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or References Thakur B, Dubey P, Benitez J, Torres JP, Reddy S, Shokar N, et al