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The serum level of intact IGFBP3 is normal in CKD, while the fragmented fraction (29 kDa) is increased but has a reduced affinity for peptides [24]
Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate
doi: 10.1016/j.amjmed.2003.08.027
Pastor et al., 1999)
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