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Janes K, Wahlman C, Little Joshua W et al (2014) Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy

For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101

[PMID: 23549581]

This T3 reduction is hypothesized to mimic the physiological response seen during fasting or marked caloric restriction, while TSH remains stable because central feedback perceives the lower T3 as an adaptive, not a pathological, state

These activities of ALCAR were observed not only in androgen-dependent (LNCaP cells) and androgen-independent metastatic PCa cells (PC-3 and DU145), but also in BPH cell lines, which represent a pre-neoplastic stage