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Lung epithelial cells with higher IRP2 expressions are accompanied by increased secretion of airway mucus, elevated airway remodeling, dysregulated infiltrated immune cells expressing inflammatory mediators (IL-33, IL-6), which contribute to the severity of acute COPD exacerbations secretion, and declined FEV1 in CS-induced COPD mice [86, 89, 90]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Noctor G, Queval G, Mhamdi A, Chaouch S, Foyer CH

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Campbell J.D., McDonough J.E., Zeskind J.E., Hackett T.L., Pechkovsky D.V., Brandsma C.-A., Suzuki M., Gosselink J.V., Liu G., Alekseyev Y.O., et al