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Dosage (g/kg) T max C max AUC 0-t AUC 0- MRT t 1/2 F a (min) (ng/ml) (ngmin/ml) (ngmin/ml) (min) (min) (%) 6 6.33 3.14 1.05 0.429 29.0 2.68 30.0 3.11 25.8 7.35 20.0 5.53 45.27 24.85 30 8.67 5.54 3.30 0.508 160 21.0 164 21.5 37.0 7.77 25.5 7.08 47.64 18.09 150 8.17 2.99 26.1 7.82 830 247 831 246 31.4 15.2 29.3 5.06 50.56 27.01 T max , time to peak concentration of drug in plasma

Neuromodulatory effect of 4-(methylthio)butyl isothiocyanate against 3-nitropropionic acid induced oxidative impairments in human dopaminergic SH-SY5Y cells via BDNF/CREB/TrkB pathway

Neuron 102(1):7590 Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders

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This eventually led to another FDA approval for the treatment of glabellar lines in 2002