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Alcohol Use Disorder, Neurodegeneration, Alzheimers and Parkinsons Disease: Interplay between Oxidative Stress, Neuroimmune Response and Excitotoxicity

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In the context of anti-ferroptosis, Nrf2s target genes include not only the iron storage proteins FTH1 and FTL and the System Xc subunit SLC7A11, but also enzymes involved in GSH synthesis and regeneration (GCLC, GCLM) and heme oxygenase-1 (HMOX1), thereby systematically enhancing the cells capacity to resist ferroptosis ( 3 Core role of the sex hormone-ferroptosis axis in sex differences in atherosclerosis Sex hormones, primarily estrogen (represented by 17-estradiol, E2) and androgens (represented by testosterone), precise fine, multidimensional, and often opposing sex-specific regulation on the molecular network of ferroptosis at both transcriptional and non-transcriptional levels through their respective nuclear receptors (ERs and AR) and membrane receptor-mediated non-genomic effects (Table 1)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Soto-Martin EC, Warnke I, Farquharson FM, et al