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Additional studies have demonstrated that the biologicals effects of thalidomide and IMiDs result from their binding to cereblon, which culminates in the ubiquitination and degradation of neo-substrates 47

While ncRNAs play a major role in therapeutic resistance, they can function as regulated cell death (RCD) accelerators that modulate therapeutic sensitivity

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Gargouri et al., Negative regulation of the nitrate assimilation pathway Nitrate assimilation is quickly blocked by ammonium addition