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The more consequential development for DCT neurology market growth is the FDA and EMA's increasing receptivity to digital outcome assessments (DOAs) as primary endpoints in pivotal rare disease submissions a position reflected in growing scientific advice correspondence and in the number of Phase III neurology programs formally designating DOA instruments as primary or key secondary endpoints

Patients with NTRK fusions should receive larotrectinib or entrectinib with serial ctDNA or tissue sequencing at progression to identify resistance mutations guiding selitrectinib-based salvage
Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy
Unlike conventional supplements, many peptides are administered through subcutaneous or intramuscular injection, often obtained through nonregulated sources with uncertain sterility, concentration accuracy, and compositional reliability (Wang et al
