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Fluctuations in the hormones estrogen and progesterone are the main culprits, as they can stimulate pigment-producing cells (melanocytes) to overproduce melanin

used a solution of ammonium hydroxide in MeOH and tetraethoxysilane as precursors for SiO 2 NPs, enabling cost-effective and easily prepared SiO 2 NPs that exhibited high sensitivity in the femtomolar range for high-throughput MALDI-MS analysis of peptide mixtures

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Ahmed S, Mahmood Z, Zahid S