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While it appears to be clear that HO-1 functional activity is important for its vascular protection as will be discussed in Section HO System, Enzymatic Byproducts and Protection Against Atherosclerosis, there is a possibility that various stimuli or microenvironments could lead to changes in the specific enzymatic activity, which is the HO-1 enzymatic activity/HO-1 protein

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2024) justifying the concentrations used in this study

Mechanistically, autoantibodies directed against AMPA-Rs and NMDA-Rs decrease the numbers of the cell-surface receptors [63] and anti-AMPA-RAb may act as agonists and increase cell excitability [66]