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Different studies have shown that vitamin C acts as a multiorgan targeting agent and can play a role in epigenetic level, regulation of kinase activity, inhibition of epithelialtomesenchymal transition (EMT), immunoregulatory effect, increasing oxygen sensation, prooxidant activity, etc

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CONCLUSION Although topical glutathione shows promise for dermatological applications, further larger randomized controlled trials with long-term follow-up are necessary to evaluate its utility more comprehensively in improving hyperpigmentation, erythema, and reducing free-radical damage

Han BI, Lee HW, Ryu S, Kim JS