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Description
The rational design and synthesis of TLK199 was based on the principle that modulation of drug resistance could be utilized as a viable clinical approach to cancer treatment

Borchers K
doi: 10.1111/j.1365-2036.2005.02333.x
Regulation of adipose-derived fatty acid flux to the liver-impact on metabolic dysfunction-associated steatotic liver disease

Apart from melanonychia, these conditions also present with mucosal pigmentation (in all three conditions) and gastrointestinal malignancies (in Peutz-Jegher and Touraine syndrome)
