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Single phospho-null or phospho-mimic mutants induce similar Golgi fragmentation levels to WT ArfGAP1 (85% cells)

When levels are low, cells are left more vulnerable to oxidative damage accelerating the aging process and increasing the risk of various chronic diseases

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A study revealed that metformin treatment induced temporal alterations in the expression of specific genes ( BCL2L11 , CDH1 , and CDKN1A ) and proteins in EC cell lines, demonstrating its anti-tumor and anti-proliferative properties in individuals with EC and PCOS (Lange et al., 2021)

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