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Chronic activation of inflammasome signaling in microglia and astrocytes, characterized by the upregulation of NLRP3 and NF-B, has been linked to the establishment of a neuroinflammatory environment, leading to synaptic loss and exacerbating tau pathology
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Chalcone synthase is the first committed enzyme in the plant flavonoid biosynthesis pathway, yet shows low product specificity in vitro
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