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The two active sites of cyclooxygenase are located close to each other (Figure 1.1-4a), and it is believed that this proximity is important in the priming of the cyclooxygenase site
3.5.2 Inadequate precision in metabolic regulation Emerging evidence highlights the multi-organ (hepaticrenalintestinal) coordination of urate metabolism, yet existing pharmacotherapies predominantly target single nodes (e.g., XO or URAT1)
doi: 10.1159/000490352
Gut microbiota and IBD: causation or correlation
That is why complexes of PAs with high number of N-groups supposed to enhance chelation mechanism (Lvaas, 1997)
