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The first two stages are integrated into the methionine cycle, while the subsequent two phases are integral components of the transsulfuration pathway

Elucidating both therapeutic mechanisms and toxicity pathways proves essential for novel therapeutic development and enhancing clinical safety parameters in pharmacological applications

[DOI] [PMC free article] [PubMed] [Google Scholar] 377.Zhu Z., Wan X., Liu J., Zhang D., Luo P., Du W., Chen L., Su J., Hang D., Zhou J., et al

Redox imbalance is a key pathogenic mechanism in melanoma and non-melanoma skin cancers, with activation of the NRF2-ARE pathway acting as an intrinsic defense against oxidative stress
