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Of note, lysine methyltransferases (KMTs) have higher Km values for SAM than protein arginine methyltransferases (PRMTs), hence the overall lysine methylation levels on H3 are easier to be reduced when SAM/SAH ratio fluctuates under the condition of cofactor competition by NNMT [55]

There is also ample evidence to demonstrate that stimulation of the melanocortin pathway by inflammatory cytokines results in cachexia

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Principle coordinates analyses (PCoAs) were generated based on the distance and dissimilarity matrices