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These results collectively signified the importance of enhancing chondrocyte quality for the improvement of final clinical outcomes

In addition to murine models, larger animals such as rabbit, dog, sheep, and bovine have played an important role as their IVDs are more similar in size and mechanical load to human IVDs, particularly in studies involving biomechanical changes over time and the application of pre-clinical therapies (Sakai and Andersson, 2015)

doi: 10.1007/s00702-024-02815-w

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