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Based on previous studies with porphyrin binding maize GSTUs, this failure to bind these metabolites in planta is most likely because GSTU19 is predominantly expressed in the cytosol whereas these metabolites are synthesized in the chloroplast ( Our studies shed further light on the ability of plant GSTs to bind, and in some cases glutathione-conjugate natural and synthetic ligands, which may well influence the availability, and biological activity of such ligands

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It inhibits adhesion and cytokine release of stimulated neutrophil [67], and, in monocytes, it binds the adenosine A2 (A2A) receptors and inhibits TNF- [68,69], IL-6 [70], and IL-12 [71], while it enhances IL-10 synthesis [72,73]

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The pathogenesis might also damage newly implanted islet grafts

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