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Omaveloxolone functions by inhibiting the Keap1-mediated degradation of Nrf2, thereby facilitating its nuclear translocation and the subsequent transcription of ARE-dependent genes

Experimental evidence from liver and lung models suggests that CB1 receptor activation promotes fibrosis through enhancement of the TGF-/Smad pathway, interaction with the renin-angiotensin system, and upregulation of profibrotic markers, such as collagen and -SMA

Int J Pharm Biomed Sci

Dulhanty, A

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