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Are under 18 years of age

The physiological mechanism is plausible, the published research supports the indication, and the side-effect profile is favorable

Therefore, Crataegus pinnatifida Bunge and its metabolites may be able to ameliorate obesity by modulating fat and glucose metabolism and regulate gut microbiota

Considering an estimated average blood volume of approximately 7%8% of body weight in mice ( in vitro IC50 of 613 M for hepatocytes, taking into account the rapid distribution and metabolism occurring in vivo

Figure 35: Diagram showing action of GLP-1, GIP (incretins) and DPP-4 inhibitors, credit: Ilmari Karonen, Wikimedia