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Lazar, A

Cortical SST is primarily expressed in inhibitory INs which provide potent inhibition to neighbouring pyramidal cells, and have been designated amongst the strongest AD-associated cell type 14,20,65

Mohr A, et al

Cytotherapy, 18 (8), 10371042

Second, the final maintenance dose may be lower than what you would use with retatrutide alone, because the cagrilintide component provides additional appetite suppression and metabolic benefit that reduces the need for maximum retatrutide dosing