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Patients should seek urgent medical review if neurological symptoms worsen or fail to improve after 46 weeks of appropriate treatment

[136] [137] In the United Kingdom, a National Diet and Nutrition Survey (NDNS) was conducted in adults aged between 19 and 64 years in 20002001 [138] and in elderly individuals ( 65 years) in 199495

However, resistance to the therapy later emerged, complicating treatment management

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