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Proton pump inhibitors and osteoporosis

Exp Gerontol 40(89):685693 Arefhosseini S, Tutunchi H, Nomi-Golzar S, Mahboob S, Pouretedal Z, Ebrahimi-Mameghani M (2022) The effect of hydroxy citric acid supplementation with calorie-restricted diet on metabolic, atherogenic and inflammatory biomarkers in women with non-alcoholic fatty liver disease: a randomized controlled clinical trial

A representative study of community-dwelling elderly found that higher glutathione levels were associated with higher levels of physical health, fewer illnesses, and higher levels of self-rated health.15 As might be expected, then, GSH status has been found to parallel telomerase activity, an important indicator of lifespan.16 This depletion of GSH also shows up as progressive loss of mitochondrial function due to accumulation of damage to mtDNA.17 The ability of animal species to protect their mtDNA is directly proportional to longevity.18 GGT as Measure of Glutathione Need GGT (gamma-glutamyl transferase) is upregulated in proportion to the need for glutathione such as for the detoxification of POPs.19 It provides the rate-limiting cysteine through a catabolic salvage pathway. Increases in GGT correlate with many diseases: metabolic syndrome, both fatal and nonfatal coronary heart disease (CHD) events, atherosclerosis, fatty liver, diabetes, cancer, hypertension, and carotid intima-media thickness.2022 Of particular note, these are elevations of GGT within the supposedly normal range

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Furthermore, the presence of AX has also been implicated in the phyla Actinomycetota and Deinococcota (Deinococcus-Thermus)