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Inflammation and Cytokine Modulation MOTS-c reduces inflammatory cytokines such as TNF- and IL-6 and protects vascular tissue from inflammatory damage in high-glucose environments

not surprisingly, they are often related to epigenetic mechanisms

It is generally well-tolerated, with the following side effects [9][18]: GI symptoms (most common): Nausea, vomiting, diarrhea, and abdominal discomfort, particularly at doses above 1,200 mg/day Sulfurous taste/smell: NAC has a distinct sulfur odor and taste that some find unpleasant Headache: Occasionally reported Anaphylactoid reactions (IV use only): Infusion-related reactions including flushing, itching, bronchospasm, and hypotension occur in approximately 10-20% of patients receiving IV NAC for acetaminophen overdose [18] Upper limit: There is no established UL for NAC

Each one has a specific job, and when combined, their effects can be amplified

doi: 10.3389/fpls.2016.00782 96 KorichevaJ.GangeA