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For example, thrombin receptor activation in vascular smooth muscle cells leads to reduced levels of p27 Kip1 and increased cellular proliferation [ 92 ], while in embryonic fibroblasts the evidence suggests that thrombin receptor activation of PI3K/Akt pathways promotes cyclin D1 accumulation, cyclin D1-CDK4 activity and cell cycle progression [ 93 , 94 ]

The Role of Cholesterol in the Pathogenesis of NASH

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