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Ethylene plays a role in regulating the shelf-life of fruits and is one of the major promoters of fruit ripening

Hou X., Zaks T., Langer R., and Dong Y., Lipid Nanoparticles for mRNA Delivery, Nature Reviews Materials 6 (2021): 10781094

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In addition, GSEA highlighted the significant enrichment of several genes involved in TNF-alpha signaling via NF-kB and cell chemotaxis ( Figure 4D )
It thus avoids the limitation of hypothesis-driven methods (in systemic and non-systemic studies), which can lead researchers to overlook the effect of therapy on the entire cellular metabolism (Di Minno et al., 2019
