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Preclinical work points to a mechanism centered on 3-adrenergic receptor modulation, enhanced lipolysis, and reduced lipogenesis, largely independent of the insulin- and IGF-1-related pathways associated with full-length HGH

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doi: 10.2337/dc13-S067

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Studies testing the efficacy of NNMT inhibition on diet-induced obesity, both alone and combination with dietary agents, are currently in progress
